Let's drop a last hint for #46:

#50: Descent as guessed by Machina.

#49: Doom 64 as guessed by S.Peelman.

#48: Slice&Dice as guessed by drbunnig.

#47: Crusader Kings III as guessed by Machina.

#46: (something with Zombies probably)
Other guests at Spiffo's restaurant may actually crave *you* more than a burger.
These are the End-Times.
There was no hope of survival.
This is how you died!

#45: Ys VIII: Lacrimosa of Dana as guessed by Veknoid_Outcast.

#44: Pikmin 4 as kind of guessed (right series) by S.Peelman.
Again brave space travelers crash land on this strange planet.
And again find help from these little colorful creatures that follow them around and do different task.

#43: Deathloop as guessed by Machina.

#42:
Muhahaha! You think you outsmarted me, the mighty Moldorc?! I don't think so, Yoked Girth!
What is Ominent Technologies deal?

#41: Starcraft/Broodwar as guessed by UnderwaterFunktown.
What the hell is that? Looks like the ground there is alive.
Should we join forces with Arcturus Mengsk?

So it is Pikmin 2.

Heh. It is incorrect, and I have to admit I didn't think about that game at all when I wrote the hint, but I see how it fits quite well. Or does it, NSMB2 and NSMBU released a couple months from each other, mine released a lot closer than that.

No, it is actually Pikmin 4. I give it to you, as I realise my hints fit every Pikmin after the first. I should've put in something more specific. And you correctly got the series.

Three guessed, two remain. Here's another set of hints.

#35

-Elder Crossing

-You are a member of the fifth fleet

#34

-Lord of Calamity Tales of Berseria

#33

-Each kingdom stands in ruins, their kings long gone, but the queens still remain

-The queens are the fragments of the primordial man

#32

-The main character becomes a teacher at a military academy after being a student in the previous two games The Legend of Heroes: Trails of Cold Steel III

#31

-A journey for revenge brings little else beyond death and misery for everyone involved The Last of Us Part II

You spelled Arcturus wrong but I'm guessing Starcraft?

Don't think I know 46, but something with zombies probably.

33) Might as well give it another shot. Dark Souls II?

Alright still 3 games left of this batch. Let's see if this helps:

39) Though the game has no combat you can wield an axe and bring it with you suprisingly far

You can also paint QR codes with buckets of white paint (which is weird since a lot of it is black)

Unlike the recent sequel everything in this game takes place in a simulation

38) There's two of you and both become party members

A JRPG for the PS2 and later 3DS

Luke, Tear, Jade, Guy, Natalia, Anise, Asch

37) The owls are not what they seem (again)

The combat was completely redesigned from the first game, it makes for great gameplay but does feel a little strange given the main character

Though both games can be said to be metroidvanias, this one fits the genre a little more

Well yeah, I did stretch the definition of simultaneous to make my guess work. But clearly that was the wrong way to go!

Correct. Nashandra, Elana, Nadalia, and Alsanna are all formed from the fragments of the soul of Manus, the Primordial man, each encompassing some aspect of his personality.

Right, it is the first Starcraft. And you're right, I did misspell Arcturus, how inexcusable of me to massacre the name of Citizen Mengsk, I mean Imperator Mengsk.

And you're right, something with Zombies. But that isn't telling much, isn't it?