Other: Xenogears
Although, perhaps it would have to be a straight up HD2D port, as remaking Xenogears into a full 3D Xenoblade style game would be a significantly larger game than Monolithsoft (or Nintendo) has ever made. XCX and Witcher 3 have the largest cities ever on a Nintendo console: New LA, Novigrad, and Beauclair - I see those as rough equivalents to the cities of Shevat, Nortune, and Bledavik in Xenogears. But then they would have Oxenfurt sized cities like Dazil and Nisan. But that's ignoring the big one, the country of Solaris, which would be significantly larger than any of those cities.
The original Xenogears didn't have that big of an explorable area because it did the Chrono Trigger thing where it allowed access only to specific parts of much larger cities; but in Xenogears the cities were far larger, and the explorable areas were also far larger. The thing is modern design philosophy where if you see it you can go there. Monolithsoft wouldn't leave those areas as background. This leaves two choices: 1. the player would be able to go everywhere meaning the largest city building dev task off all time, or 2. a compromised vision - which would kind of defeat the purpose of a remake in the eyes of most Xenogears fans (as Xenogears is already famously a compromised vision).
I've been thinking of the Yggdrasil in a modern scale design. Holy crap that thing would be awesome. I think the closest thing we have to a city in an Airship is Skies of Arcadia - the Delphinus.
There's an ocean-going ship city called the Thames in Xenogears, and Xenoblade Chronicles 2 has something similar (if I remember XC2 correctly).
The Zeboim civilization ruins would be phenomenal. But what I'd really like to see is a fleshed out city to explore during the 4000 year old flashback sequence - I doubt it would happen - probably like Tir Na Lia in Witcher 3, which is kind of like what the scene is like in Xenogears. Morytha in Xenoblade Chronicles 2 is also similar to Zeboim Civilization, although it comes from a different part of the 10000 year old timeline. In Xenogears, the beginning of the timeline is similar to Xenoblade Chronicles X where a giant spaceship crash-lands on a planet, and 6000 years later Zeboim civilization had developed - a metropolis-level and then apocalypse... where Morytha was destroyed by its apocalypse about 10000 years prior and there's not really anything about the build-up.
But anyway, a remake of Xenogears would easily be the game I want most of any game. Without compromise.