Maybe.  Probably.  Hard to say until S2 specs are confirmed.  

Nah, this isn't a matter of spec or popularity, otherwise GTAV would have made its way on the platform loooooong ago.

Although with the increasing obsolescence of the Xbox brand, you never know if they'll have to resort for a port on another console. Though who am I kidding. It'll be their new Graal the moment it's put on PC really

Nintendo published/distributed GTA Trilogy on Switch (the physical version), I think they have been warming relations with Rockstar for a while. I wouldn't be that surprised if it comes.

I'm on the fence on GTA6 hitting the S2. I guess it depends on how hard it is to port. My assumption is portables will struggle with it.

I'm not an expert on any of this stuff but this team of 25 managed to release a Switch port of Hogwarts Legacy port and a MK 1 port last year. If I am not mistaken, most ports teams are 20 people at most (but I don't know how that figure has changed with more recent generations and technologies). Obviously GTA6 is a very large scale game, so it might need some more resources to its port. But I can't see it reaching 100 active staff porting it.

I think that PC ports are bad for hardware makers because they devalue the hardware. Nintendo putting games on PC Microsoft learned that the hard way with Xbox now having to put games on competing platforms and now that Sony's most successful games of the year are on PC ghost of Tsushima and helldivers they are going to devalue the ps5 hardware for short term gains. 

You don't need 100s of people for any kind of port. 

100+ people is like if you're literally re-doing art assets, re-doing entire game sections, making new poly models. As you said, this same team of like 20-25 people ported Hogwarts Legacy to the Switch, and that's a pretty massive game itself. 

The Mortal Kombat games have a shit ton of content too. 

That is pretty damn impressive.  Seems like a good purchase.  

And this time I think the likely promises Nintendo will make as Switch 2 comes out will remain.

Nintendo promised robust third-party support on Wii U and that crashed and burned within about a year. Most of that was Wii U's architecture, sluggish sales after launch, and GamePad. 

This acquisition from Nintendo seems like a great idea, with more third-party games on the way for Switch 2. 

All I saw from GTA6 is a cinematic trailer. This game went in development loooooonnnnnnggggg time ago. I could imagine when they started, they had no idea what a PS5/Xbox Series could do, so the game was developed with PS4 pro-ish in mind.