Well if it has Mario, Zelda, Pokemon and Monster Hunter, plus some of the smaller Japanese titles, than it will sell gangbusters in Japan. Possibly even match Wii U sales from that one country alone.
In the west, it will do ok, nothing more. Again, having all these big Nintendo titles in one place is going to be a great selling point, and I think the mere fact that Pokemon will be on the system will see growth for Nintendo in NA and EU.
It is hard to say, but 40-45m is my guess. Would love to know Nintendo's projections for the system long-term.