#40 - Someone solved the complicated rights issues around this game, because it was finally ported to modern systems in early 2023

#39 - The fourth iteration of one of the most important arcade games of all time, this title introduces four new characters

#38 - An iconic character strives to break up a shotgun marriage in this acclaimed video game

#37 - Designed primarily by one man, this modern JRPG masterpiece channels Final Fantasy, Chrono Trigger, Xenogears, and Suikoden

#36 - The iconic character from #38 also stars in this game, which is the (double) cherry on top

My guesses would be:

40 Goldeneye

39 Super Street Fighter II

38 Super Mario Odyssey

36 Super Mario 3D World

Two games left for now, a new clue for each.

#35: Tales of Berseria

• Though most games in this long-running series are unrelated to each other, this entry was is set in the same world as the previous entry in it, set around a 1000 years earlier.

#34:

• The game received an updated version a year after release that made some changes to features such as enemy positioning and behavior, and also added some new details to the story, including a new final boss that appears if you complete certain requirements beforehand.
• Said new final boss was also the namesake of this updated version, though he wasn't directly named in the subtitle bur rather referred to by a specific title.

#33: The Legend of Heroes: Trails of Cold Steel III

• After two games of student life, the main character has now become a teacher in a newly established branch of a military academy.

#32: The Last of Us Part II

• About halfway through the story the perspective suddenly switches to who up to that point had been the game's main antagonist.

#31:

• Details the events of a secret offensive during the second Europan War.
• Takes place at the same time as the first game in the series.

#40 - Someone solved the complicated rights issues around this game, because it was finally ported to modern systems in early 2023

#39 - The fourth iteration of one of the most important arcade games of all time, this title introduces four new characters

#38 - An iconic character strives to break up a shotgun marriage in this acclaimed video game

#37 - Designed primarily by one man, this modern JRPG masterpiece channels Final Fantasy, Chrono Trigger, Xenogears, and Suikoden

#36 - The iconic character from #38 also stars in this game, which is the (double) cherry on top

Hints for the next two!

#37 - This is a sequel to a game that notoriously dropped a lot of "content" from earlier games in the series - for this one, they brought a lot of that "content" back.

#36 - Still the latest entry in this sub-series, but after a very long wait, that's soon to change.

#49 You basicly start out as a werewolf but eventually become an animagus

• Nightfall royalty
• Specifically you turn into a wolf with an earring, first you can't change back, later you can switch at will

31) Valkyria Chronicles?

Gotcha. Will have to remember that.

That said - could #41 be Cat Quest?

50 - Eternal Darkness: Sanity's Requiem (incorrect guesses - Pokemon Blue + Red)
- Red > Green. Green > Blue. Blue > Red. Purple > all.
- An exclusive, mature title on a console that had a reputation for catering to younger gamers.

49
- There could be up to 4 previously unvisited countries on your itinerary.
- England, Mexico, Jamaica, Hong Kong

48
- Those precious collectibles are found in the levels here, rather than in bonus stages like in its more powerful namesake.
- This game was first available on both a home console and a handheld.

47
- Robotic animals take each other out in a title from the developer of one of the biggest franchises of all time.
- You have to take control of these robotic animals to do combat, solve puzzles, and get to each level exit.

46 (incorrect guesses - Psychonauts)
- The playable character is like the antithesis of Freddy Krueger
- A Zelda-like game exclusive to one of Nintendo’s rivals.

45
- Solving everyone else’s problems whilst trying to solve your own.
- A handheld title that produced one sequel. Fans hope for a remaster one day (much like two similar games from the same, now defunct, developer), or maybe even a third game.