All Nope. 

And it's worth pointing out, the song was made for the game, not just included in the game. (Seriously, I figured this was by far the easiest hint)

AS for Mass Effect 2, holy shit that's uncanny but no. It's family friendly. 

50 - This game's theme song was so popular and well-liked they released it on the video game Rock Band
- The campaign is only about 4-5 hours long on a first playthrough but as little as 1-2 for experienced players.
- There was a second entry in the franchise which is also on my list. There was no third, but there have been side-games.

49 - The PS2 and Xbox 360 versions of the game were mostly identical but the Xbox 360 version had a bit more unique content.
- This game is what really propelled a genre into the mainstream, only to have it fizzle out a few years later.
- It's direct sequel was 80's themed and only done to fulfil contract requirements.

48 - This beloved classic leaned into the genre's more campy elements and is widely considered a masterpiece for it.
- It might be one of the most remastered and rereleased games of all time, and the company recently redid its prequels to great success.
- While originally meant to be a Gamecube exclusive, it was quickly ported to PS2 and has since been on basically every console ever.

47 - This game left people wondering if the protagonist was human or not, given his relations to other humans within the game world.
- It is also one of the highest rated games of all time and the best-selling in its franchise.
- You can get up to 999 of the main collectible, but there are 880 unique tasks to get them.

46 - Your ally is a vegetable and your enemy is an idiot.
- This game is a sequel to another game already on the list.
- This sequel added a co-op mode that, while not as story rich, I've never actually completed due to not having a coop partner to do it with!

45 - What's gravity? Infinity, that's what.
- This game got a remake that sold better than the original.
- shockingly, this game had a mercedes partnership/marketing push.

44 - Axiom Verge

43 - The Messenger

42 - For the first time ever in this sequel, you can play as the main hero's best friend in their own unique campaign.
- It is the fourth entry in the series, which is in its own is a side-series to a game that has been around since the NES
- This entry is well-known for remaining 2D in an era where almost all other platformers were going 3D.

41 - Red Dead Redemption

40 - This game helped to popularize the idea of selling to customers before the official game was released.

#47#48 Resident Evil 4 (EDIT: typed the wrong number)

#46 Resident Evil 5

#45 Mario Kart 8

I never played the original Resident Evil back then it first release, as in the 90s I didn't play on console. So my first exposure was the rerelease on Wii. I actually played Resident Evil 4 first, and as I liked that game, I bought *every* Resident Evil for the system. Yes, including Umbrella and Darkside Chronicles. Of all these games I liked RE1 the most.

Yes, I wasn't repelled by the old control scheme as many others were. But Resident Evil excels in another area: atmosphere. The atmosphere of the creepy villa and then the lab. The game always keeps you on your toes, although it has way less enemies than later entries. Every time you start to feel secure, because you start to amass ammunition, know how to kill the Zombies or find your way around the villa, the game adds a spin to keep you unsettled. This is in the best sense of the word survival horror. And that makes it so great and keeps the game in my TOP 50, although yes the controls and visuals are dated.

The game is a mix of a shooter, but with fixed camera angles which certainly makes shooting a bit cumbersome, survival horror and light puzzles. You find your way through the villa and lab, searching for keys or items that help you progress and slowly uncover the truth about what happened here. The game keeps your resources as healing and ammunition sparse, so it often is a prudent tactic just to run through a room with an enemy instead of wasting bullets.

And yes, as I played the reworked version starting from Gamecube, it probably already got some improvements. Most visibly the graphics. Look at the pictures above and below for comparison.

From this game (the original blocky version) spawned a whole big franchise, with many games and movies. This success started here, despite controls, despite all it's shortcoming, because it does so well on the creepiness, on the unsettling feelings, on the jump-scares (who doesn't remember the zombie dogs). So it deserves it's place on my list. The game itself got countless rereleases, including on Switch which is another version I bought.

https://www.youtube.com/watch?v=5ppxxVVJVAE&ab_channel=GameSpotTrailers

Damn you Raccoon, I just saw that #50 hint and was about to guess it! 

#37 is still unguessed:

#39: Baldur's Gate III guessed by UnderwaterFunktown

#38: Pikmin guessed by cosmic_drift

#37
Your first task: dig out a skull.
Said skull gives you pointers what to do next.
Plant and harvest crop, make wine and beer, give sermons, mine, craft, cook and in the DLC even run a tavern, but don't forget your actual job.

#36: Assassins Creed Odyssey guessed by Jpcc86

@Runa216 : #49 is probably Guitar Hero.

#47: Mario Odyssey

48 - Yes! Finally! I wondered when people would get it. 

46 - Naw. I liked Resident Evil 5, but not enough for it to be on this list. 

45 - Also yes! Good shit! 

@TruckOSaurus Close enough. It's actually Guitar Hero II, but I'll let it pass! 

Yup that's the one!

#37: Planetscape Torment?