I believe this is Turrican??? it released on the GB as well. 

You are again correct!

#50 must be One Must Fall, a great game which was in the past on my list too. I love how your mechanic is mad at you if you won, but got a lot of damage. And the news reports about your fight.

Yeah, I saw you had it in 2017 on your list - and even on the same spot.

And I love the mechanic too. He rants if you do badly, but if you do well, he brags that you certainly must have watched his old fights...

42) Hotline Miami

I'll be honest, I don't have a lot of patience with indie games. Games that others seem to see as quirky and unique I just see as tiresome and frustrating with poor production values. And yet, a game like this just couldn't have worked in any other style than low-res top-down 8 bit. It's nothing like the first game of its kind and yet it feels amazingly fresh - the slightly creepy Miami setting, the ridiculously over-the-top gore, the fast pace, and those cool animal-mask powers all combine to make this game actually quite a profound emotional experience and a huge amount of fun despite the frustration of having to play some levels over and over again.

42 l080 n64
i dont know what to say it felt like actual boarding back then and dont forget the MP

Spiritfarer caught my attention right away I saw it the first time in an Xbox presentation. Later it was shown in a Nintendo Direct... and released right away, so I picked it up.

In Spiritfarer you play Stella, who meets in the beginning Charon. He is retiring, so he gives you the job as the new ferrymen. As the most important tool he gives you the everlight. Daffodil - your cat - grabs one as well and can be played by a coop-partner. After that he sends you out to find a boat, as he explain one will materialize for you, as it always do. And so you set out in the world. You get your boat, you find the deer spirit Gwen, who helps you introducing you to your gameplay.

From then on you basically ferry around the world, collect materials to create buildings on your ferry. You also meet spirits of deceased person which you take onto your ferry. Each of them is taking on the form of an animal. They all have wishes in form of quests, which you go on to satisfy. In the time you get to know each spirit better, as they talk about the life they had, the things that they enjoy, their fears and so on.

Once they are reaching a certain point the spirits are ready to move on, and you go on and bring them to the everdoor, to reach the afterlife. So in basic the gameplay loop is: befriend spirits and once you are good friend with them say goodbye forever.

Despite it's themes the game feels kind of positive about all. It celebrates the life instead of dwelling on the death. Especially in 2020 and with stress from work it gave me some needed relaxation.

The world consists of different islands with different inhabitants and resources. You also have some events in which you can collect resources, for instance you can catch lightning in a bottle in a thunderstorm. And obviously this raccoon is asking way too high prices for what it's selling!

The game has a pretty comic-like artstyle and nice music.

Spiritfarer is released on pretty much every modern platform, so you can get it everywhere.

https://www.youtube.com/watch?v=4pKJ-NuSjNE

I guess it's time for the next bunch of games to guess.

#39: Baldur's Gate III guessed by UnderwaterFunktown
After 20 years finally we get the third mainline entry, for the moment in early access.

#38: Pikmin guessed by cosmic_drift
Your spaceship crashed on this strange planet and you need to find it's missing parts.

#37
Your first task: dig out a skull.

Here's some hints from a couple more of my games.

40.  Part of the gameplay of this game involves obtaining 3 keys to open up 3 different gates.  Kinda like the plot to Ready Player One.

39.  This gameplay on this SNES entry is closer the to the original arcade version of the series than it is to the NES entry.

39) Baldur's Gate III?