Very little to go by, but since they've decided on a tablet format and still somewhat chase a crowded market, I'd say less than the Wii U and 3DS combined for now, which means less than 80-85 million. I'm thinking way less, unless they manage to do something spectacular.
It does several things, but it does nothing that other devices don't already do in principle, and the tablet form factor in a home console environment might be more detrimental than helpful in the end, I still believe that the Gamepad was the main culprit in the Wii U's demise, this appears to be a slightly more streamlined version of basically the same idea, with the added benefit of being an actual portable.
But, even as a portable, I just doubt the tablet form factor in general, click-on controllers have been around for some time now and were never a success; traditional gaming and control schemes and smart device form factor simply aren't a very good match.
Nintendo deserve a lot of praise for being different though, and the base idea seems sound enough, but I have doubts, serious ones at that. Let's hope I'm wrong.
Depending on price and support, and just how much they're going to cater to handheld fans, I might consider buying one though.