Even with erosion from the mobile sector, they should be able to sell 65-70 million of a hypothetical Fusion platform (home + portable variants).
That's enough for them to continue making a decent sized profit as long as the hardware is not stupidly designed.
Especially since they no longer will have a split where things like Mario 3D World can't be sold to 3DS owners, for instance, thus limiting it's profitability. Or in the past they could only sell like Wind Waker to the 20 million GameCube owners, but under the Fusion setup games like that would have access to all Nintendo hardware owners, not just the few who buy the console hardware.
Will they ever be as relevant to the overall gaming industry as they were in the 80s/90s again? Probably not. Those days are over, but they can still make some good money if they are smart in how they handle the Fusion concept.
Affordable hardware that has smart chip design choices (ones that scale downwards in cost quickly) is a must next time. The 3DS and Wii U use too many propietary components and over rely on non-standard gimmicks like 3D screens and tablet controllers that drove their hardware price too high.