A reboot of Megaman X, with full english voice acting (make X sound cool, not like a girl), more levels than the standard Megaman game, lots of cutscenes, man I wish they had made a full anime based on it.

A spinoff Zelda game that tells the story of Fierce Deity, such a sweet character they should use him more often.

A Sonic/Megaman crossover game... They have comics, they just need a game now... Hell, I'd take anything Megaman at this point.

Zelda HD Collection: Twilight Princess and Skyward Sword receiving the same treatment as Wind Waker, would be awesome.

A Lord of the Rings game that centers on Boromir before he was sent to Rivendell. With full voice acting by the one and only Sean Bean of course.

But these are just dreams, and I being poor have only my dreams. I have spread my dreams under your feet, tread softly because you tread on my dreams.

I would stand up and leave, quit playing games forever, i would find no joy in gaming anymore because all of it would be consumed by this announcement, all of it would be gone at this very moment... i'm fear it would be just too much too handle

on topic:

New Games, in order of happines they would produce: Megaman X9, Dragon Ball Budokai Tenkaichi 4(any platform)/BT style game for 3DS, Warcraft 4, anything with Crash Bandicoot on it, Metal Slug 8, a game starring Bowser, Grand Theft Auto: San Andreas Stories/Episodes , Onimusha 5, Devil May Cry 5, Darksiders 3

Remakes, same order: Final Fantasy VI, Chrono Trigger, Castlevania SOTN, Final Fantasy IV, Xenogears, Grand Theft Auto: San Andreas

The honest to god, no bullshit, just as good but actually better than SF64, HD STAR FOX that I've been dreaming of forever.

That series was in the dumps for so goddamn long. SF64 was literally the last entry (Dinosaur Planet doesn't count) worth a shit. If they unveiled a REAL, GOOD looking SF at E3, I'd be totally happy.

That and a new Wave Race.

Zelda U - My poor head is going to explode on June 10th...

Other than that a main series Pokemon game for Wii U.

Elite Beat Agents 3D, Metroid U
battletoads, banjo, conker

Lost Odyssey 2 but since that isn't going to happen I will be very happy with Forza Horizon 2's official unveiling.

Not going to happen the game already sold more then enough to be highly profitable.  At this point I wouldn't even expect a PC port anytime soon.

Last Story 2. Or a new, exciting IP.

Chrono Trigger 2 or at least Chrono Trigger Remake.

Dragon Quest VII localization for NA ;-;