Pokemon RPG for the Wii U, much like Colosseum and XD: Gale of Darkness.

It is interesting to see how many Wii U titles are on this thread.

Zelda U, though we already know that will be shown. I will scream like a little girl when they show the first footage.

Monolith Soft's "X" will be shown but, my head explodes from happiness every time I see or learn anything new about that game. I want a title and I would flip if it was confirmed to be directly connected to Xenoblade...especially if that guy at the end of the first trailer IS Shulk.

Kingdom Hearts 3 for Wii U would make me VERY happy...though if not, I guess I'll be getting a PS4 eventually.

Beyond that, I would love a TRUE sequel to Super Mario 64, with wide open sandbox environments and no time limit.

I'd also love a sequel to Fire Emblem: Awakening on 3DS or just for SMT X FE to PLAY like Fire Emblem rather than SMT.

Pokemon Snap 2 for Wii U.

Twilight Princess and Skyward Sword HD collection for Wii U.

A Kid Icarus game done like Kid Icarus: Uprising, but for Wii U.

Paper Mario U, a true RPG like the first two Paper Mario games.

Pokemon Electric/Lightning Yellow remake for 3DS made in the style and with the improvements of X/Y.

The Last Story 2 for Wii U. 

THAT Pokemon game.

Aladdin. Jade Empire 2 would be nice too.

Lost Odyssey sequel would make me explode with happiness!!!!!!!!!!!!!!
No one wants a sequel to this game more than me.

Half-Life 3
2D Metroid from Nintendo SPD and Intelligent Systems
3D Metroid from Retro in collaboration with Crytek (just for graphics)
Pokémon MMO from Gamefreak and Monolith Soft
Shenmue 3
Half-Life 3
No One Lives Forever 3
System Shock 3
Nintendo vs. SNK vs. Capcom
The Wonderful 102
Okami 2 (Nintendo buys the license from Capcom that Platinum can make the game)
Resident Evil 2 Remake
Quake V Arena (MP focussed) to bring back the good old Quake vs. UT days
Crash Bandicoot from Naughty Dog
Baldur's Gate 3

Nintendo buys Mega Man IP
Super hard DLC for 3D World and Tropical Freeze

Phantasy Star Online 2 gets ported to Wii U.

Bushido blade 3
Megaman Legends 3
No one lives forever 3, or at least news that someone found the damn rights to the series so the games could be put on steam or gog.

Sonic adventure 3.

Super mario 64 the Unifying

Super Paper Mario sequal

Left 4 dead 3

like the op said star fox X Metroid but adding F-zero into the mix and being open world will make me shit bricks and rainbows for weeks.

and