I don't like the wii version with pointer. With the normal controls it's probably best version if you have dolphin. If you like pointer controls, and don't like RE tank controls then this is best.
As far as I know the HD versions is the same thing except in 720p. So if you don't have dolphin and don't like pointer controls (no move support), it might be the best version for you. They didn't update any textures from the wii version.
The PC version has texture, model (Increase polygon count), lighting mods which make the game look the best. However, picking the mods and deciding which ones you like is a project in itself, you have to find patches because it was originally a buggy mess. It also has no rumble support and the cutscenes are FMV's instead of ingame like the Wii, GC, and HD versions.
I own and have beaten the GC, Wii, and PC versions. I haven't played the HD versions because I had no reason to so I can't confirm they have meh controls like the person above, or say if theres anything really irritating about that version.