1. Uncharted
2. Resistance
3. Assassin's Creed
4. Mass Effect
5. Bioschock

Honorable Mentions too: Infamous, LBP and Gears

1. Uncharted
2. Dead Rising
3. Assassins Creed
4. InFamous
5. Lost Odyssey

1. Mass Effect
2. Wii Series (Someone needs to give it some credit)
3. LittleBigPlanet
4. Assassin's Creed
5. Minecraft

1. Soul Series
2. Uncharted
3. Mass efect
4. Bioshock
5. Assassins creed (AC3 really put me off the series tho...)

1.Wii Sports (The TRUE most influential game of this generation)
2.Gears of War
3.Portal
4.Uncharted
5.Minecraft

Edit:Only truly played 3 of 5 the other 2 is based off of sales and influence to the gaming industry.

1. Wii Sports
2. TWEWY
3. Ouendan (Elite Beat Agent)
4. Wii Fit
5. Boom Blox

1. LittleBigPlanet
2. Uncharted
3. Portal
4. Playstation All Stars
5. Left4Dead

1: 999/zero escape
2: Layton
3: Portal
4: Bioshock
5: Mass Effect

I'm not going to put single games because that's a bit silly imo so TWEWY, Lost Odyssey, Xenoblade won't be on it.

1. Soul's Series
2. Dead Space
3. Bioshock (This is iffy, since it's sort of a spiritual successor to System Shock. Though since it's much more shooter-y I'll count it).
4. Mass Effect
5. Chaos Rings

Isn't Xenoblade still part of the Xeno-IP though? Not a direct sequel sure but still part of a series.