Best lineup in absolute terms (what interests the most people), or what I'm looking forward to personally? I can guarantee you that most people will just say their favorite console in either case.
Not to break my own prediction, I find the Wii's lineup to be by far the most interesting. It would be so just for Brawl, but on top of that there's No More Heroes, Okami, the brilliant Zack&Wiki that I bought yesterday, and a bunch of stuff that can be Q2 or Q3, so I won't list them.
I have no interest in GTA, or racing games, and I find all the FPS coming out to look pretty generic, so that rules out a good chunk of the HD console's offering for me. =/