Of course everyone knows Nintendo stepped up and they did, they brought even more great games then they did during the GameCube era and successfully changed the industry for good.

But as far as third party publisher I would say the publisher that stepped up the most this generation would have to be EAGames. Prior to this generation EA was known for lisenced titles and those titles were mediocre they were nothing amazing. But this generation EA stepped up their game in a big way with aquisitions and founding new studios. Bringing new series like Mass Effect, Dragon Age, Dead Space ,Crysis ,Army of Two, Battlefield (To consoles) as well as bringing back reboots of games like SSX, Medal of Honour and soon Syndicate. Then lets not forget the many other new franchises EA is fostering like Mirrors Edge, Dante's Inferno and lets not forget Command and Conquers reboot expected soon. Then with StarWars:TheOldRepublic EA is proving they can make a very high quality lisensed title to compliment their growing line up of internal IP!
EAGames started this generation off a little slow doing their usual thing relying on lisensed material. But within the generation they turned their whole strategy on its head and created through themselves and other studio partners franchises that would help shape a generation. Activision's few successful titles pale in comparison to what EA has done this generation. EA are my hero's this generation.
As for an individual developer their are too many developers that have brought amazing things to the table this generation. Its really hard to pick any single studio out. I would say Infinity Ward, Crytek ,DICE, BioWare Alberta, UbiSoft Montreal, EA Vancouver, Rockstar North, Nintendo EAD Tokyo. Too many studios that deserve mention that stepped up their game this generation and helped shape it!