Nintendo franchises that could be comming for the Wii:
F-Zero
Animal Crossing
Pikmin
Donkey Kong (platformer)
Star Fox/Star Fox Adventures
Mario Golf/Tennis/Baseball
Kid Icarus
On top of that there will (likely) be several new franchises, with some (obviously) being centered around 'Blue-Ocean' gamers. Third party annoucements could be fairly big being that this will be the first E3 where publishers will be able to announce projects that will be worked for more than 12 months before they're released.