I have no idea really, but it sounds SciFi and has horror atmosphere and actually some of the environmental sounds remind me of the first Alien movie, so I am gonna say Alien: Isolation, because even though I haven't played it, I heard it targets to recreate the atmosphere of the first movie.

#23
- You can trust those little simians in the opening level, but after that they’re going to start attacking you.
- You visit five different locations in this game. The first and last are preset - you get to choose which order you visit the middle three in.
- The console version was less forgiving due to a different save system, and being unable to adjust the brightness of the visuals.
- Introduces new moves such as running and crawling.
- The fan base tends to split the console games in this series into three distinct groupings. This is the third of six entries in one of these particular groupings.
- The game says there’s 59 secrets to find, but it’s possible to get 60. A little leeway if you’re trying to unlock the hidden level.

#21
- Not sure how all those birds have survived so long, seeing as water damages them.
- If you beat 7 lots of 7, you’ll experience heavy flooding.
- Finding and keeping track of one of the collectibles can be quite a task.
- The developer, often praised for their attention to little details, made sure every level felt connected to each other, as well as the central hub. It’s not unusual to be able to see one level off in the distance when you’re playing in another.

#19 (incorrect guesses - Final Fantasy IX, Final Fantasy XV) Resident Evil 3
- Initially started development as a spin off, before being changed into a main entry in the series.
- Like previous games, there’s more than one playable character, but you don’t get to pick who you play as here - you’ll have to control both in every play through.
- There are, however, instances where you do get to pick how you act in certain situations, which can shape how the game unfolds. Some item and enemy locations / types are randomised too.

#18
- At the file selection screen, if you slightly misspell a prominent feature of the game, it’ll net you something good.

My list so far

19) Resident Evil 3? That started as a spin-off at least

Still none of these guessed, lets see if the 3rd hint can't fix that:

20) This game actually has two titular characters, though it's easy to assume it's the same one
Hint 2: But neither of these two characters are the protagonist
Hint 3: One is the titular character for the whole franchise while the other, referred to by their title, is unique to this entry

19) To be honest I hated the target practice mini-game
Hint 2: And wasn't too keen on the one where you balance an ice cream either
Hint 3: But neither is a big deal when the combat is off the leash

18) Joor-Zah-Frul
Hint 2: Wuld-Nah-Kest
Hint 3: No takers? Let's try this one: FUS-RO-DAH!

17) Only one line is uttered in this game's entire story mode
Hint 2: It's a pretty iconic catchphrase of the character in question, but this game is not where it originates from
Hint 3: Every other character stays silent, even the hedgehog merely waggles his finger

16) Though sales numbers have never been revealed this is probably one of the most profitable games of all-time
Hint 2: And though I'm sure they sold an awful lot of physical boxes, most of the profit didn't come from game sales themselves
Hint 3: Personally I have 6 boxes for this game on my shelf, the base game and 5 expansions

18: Skyrim.

17: A Sonic game then, but I’m not sure which one, lets go with Sonic the Hedgehog 2.

16: I thought this earlier, but then thought nah they aught to have released sales numbers at some point wouldn’t they. I’ll try it now, after the expansion comment anyway; World of Warcraft.

Yep, that's correct.

18) Exactly, guess there's one dragon shout everyone knows :D

17) Nope, not actually a Sonic game, but... you do have the right hedgehog

16) That's the one! Pretty sure they've only ever revealed active subscribers or total account numbers (which presumably includes free trials), so it's a mystery how many copies have actually been sold.

17 maybe a Smash Bros game - Smash Bros Ultimate?

You are probably right about WoW, and for #17, Sonic that's not actually a Sonic game, I'll go with Mario & Sonic at the Olympics then. To pick one.. Mario & Sonic at the Londen 2012 Olympic Games?

No to both, but drbunnig is very close. It is a Smash Bros. game, but not Ultimate.