Slime San? :D

34) Metal Gear Solid V: The Phantom Pain

Who knew an open world format would work so well for an MGS game? It makes the game feel a lot more varied: you've still got the classic gadget-powered sneaking but if you get bored of that you can just call in a massive airstrike to take out the enemy base (I never felt particularly limited in my resources in this game). There's a lot of mission variety, a really interesting plot with a few great twists, and some brilliantly realized characters.

33) Batman: Arkham City

Arkham Asylum revolutionised third-person action games but I never really connected with it. On the other hand, the open world format (there's a real theme running through my top 50 isn't there) provides some much-needed breaks from stretches of combat and puzzle solving. The combat gets even deeper; the gadgets are better this time around; and I preferred this incarnation of the plot. 

Metroid Prime 3

Seriously, are my games too hard to guess that nobody gives it a try?

#40: A very unusual RTS in space, where you start with a small capital ship and 3 planets to govern, but the map (and thus the number of planets to govern) and fleet grows at specific points in the story when you reach a new rank.

Hint #1: You start this game with your main planet almost in ruins, with most buildings massively damaged.

Hint #2: The Alien factions make war independently from you, even way before you have even the rank and thus ability to contact them, quite possibly eliminating some races before you ever had the chance to meet them.

Hint #3: Your quarters are on your main capital ship, and you can move around there when not looking at the sector map.

Hint #4: In the end, you're about to build a galactic empire.

Hint #5: The name of the game is in latin

#38: A PC-exclusive Pinball game with a horror theme.

Hint #1: Tables are a haunted Castle, a Dungeon, and Frankenstein's Laboratory, complete with the Monster in it's center.

Hint #2: It's the second game in that specific series, 3 more were to follow.

Hint#3: The predecessor had 3 tables in space, with buildings from Outpost, the successor had Dinosaurs, the next one had a NASCAR theme and the final one a rollercoaster theme.

Hint #4: They also made a Minigolf game with an identical naming scheme, just switching out the Pinball at the end for Minigolf.

Hint #5: The series was published by Sierra On-line

#37: Bring your console-making back from the brink of death by hiring 2 kids and beat your programmers into submission in RPG-like combats.

Hint #1: This game came out shortly before the company making it stopped making consoles for good, making the premise highly ironic.

Hint #2: While most of the game is for the most part an RPG mixed with a tycoon game, the finale goes straight to Shmup, where you have to fight several iterations of Sega consoles.

Hint #3: This Dreamcast title from Sega never left the shores of Japan, but has pretty much all their IP playing some part here.

Hint #4: The evil company you have to beat is called Sigma, and is a clear stand-in for Sony's Playstation. In the game's Universe, Nintendo also existed but had to fold before Sega tried it's last stand in the game.

#32: Hire some Mercs to support a group of rebels to defeat the evil queen of the country.

Hint #1: You can hire your mercenaries from 2 different companies called A.I.M. and M.E.R.C.

Hint #2: Elliot, you Idiot! *slap* *slap*

#30: Capitalism, ho!

Hint #1: You have to pay back the debt accumulated by your father by selling stuff, most of them being adventuring related. 

#29: The successor to this game just came out, but the title before that came out over 20 years before this one got released.

Hint #1: The first part of the game plays in a devastated Arizona, followed by a destroyed California.

#28: Wacky races with 2 drivers at once, tagging in and out at will.

Mario Kart: Double Dash?

Hey, I tried alread on #40.

Anyways, your #32 has A.I.M. as hint. Association of International Mercenaries? I don't know about M.E.R.C. though, so I guess Jagged Alliance 2 (as the first game has neither M.E.R.C. nor an evil queen).

#29 simply must be Wasteland. Or more precise Wasteland 2, as it isn't the just recently released nor the first, that released a long time ago (and as the devs didn't get the rights from EA to make a new entry, they needed to invent a new name, which was Fallout - as as Bethesda took over Fallout, EA had no longer an interest in the name Wasteland, so the devs made Wasteland 2).

I already googled your #37 a few hints back, because I was highly interested to know what it is. I would have never guessed, never heard about that before. Still think someone might genuinely know the game and deserve the win on that.

#32: Pokemon Black&White 2

#28: I see to possibilities here, let's go with one of them: Splatoon 2

Yeah, Smash would've been actually my next guess. I guess these discussion if they are really new games are well present in our mind. (-:

Hmm, I remember 2 off the top of my head. I'll try FF7 Remake first.

Tag, you're it who got the right answer!

Yes to both Jagged Alliance 2 and Wasteland 2

Every time you did something, like conquering a city, Elliot brings the news to his queen - and gets slapped across the (later even shot! And he survives!) face for bringing the bad news.

And yes, the connection to Fallout would have been the next hint

And since I don't think anybody can figure out what #37 is, it's called Segagaga. Played a partly fan translated version several years ago, and was totally smitten by it.

Since you also seem very interested, here's some more information about it:

https://en.wikipedia.org/wiki/Segagaga

http://hardcoregaming101.net/segagaga/segagaga.htm (have also a look at the second page and the parody games they made)

And a couple Youtube videos:

The Intro:

https://www.youtube.com/watch?v=AQ3QAlwTJoU

Final Battle (including the final "dungeon"). Jump to 31:00 for the aforementioned shmup part:

https://www.youtube.com/watch?v=QuRWvl2-wPE

And a good review (and explanation) of the game:

https://www.youtube.com/watch?v=4ejH8c-ZEuA

For once that I knew some of your games, they've been called already...