Here are my first few clues:
50 This GBA game is based on a very old Japanese manga.
49 I will be surprised if anyone gets this one, so here's about as easy as I can make the clue. This is an early 80's arcade game where you extend your tongue through a maze to eat pellets as well as ants and worms. At night a spider comes out, which is almost impossible to kill.
48 This may be the best looking (and best overall) 2D game on a console known for 3D games with now very dated graphics.
47 This is an early 80's arcade game known for using a trackball to shoot different bugs.
46 This game makes great use of the Wii U gamepad by allowing one of the players to split up and still have their own screen.
Also I want to add some honorable mentions for games I played since last year's list, but didn't quite make the top 50:
Valkyria Chronicles 4 - Extremely fun and a good story, but the first one is probably more memorable.
Cadence of Hyrule - This is a super fun and addictive Zelda game. There is a chance this could enter the top 50 in the future depending on how much I come back to it.
Earthbound - This was fun and interesting, but I probably would have enjoyed it more if I had first played it when it was a current game.
Untitled Goose Game - This game is fun, whimsical and crafted extremely well. The main strike against it is how short it is. But it's original and a lot of fun for a few hours.
Spider-Man (PS4) - This is another good candidate for the top 50. I remember an earlier game like this being better though. At some point I need to go back and replay it and compare the two. Is the old one really better or is it just nostalgia? For now, I'm keeping the earlier game on this list.