Raise your hand if played both, and actually made an objective, informed vote lol
I've only played QB, but I think I could make a case for both in terms of which I'd prefer. QB takes some risks, and it's a very unique experience with its fairly high production quality show integrated into the story. As a game it's very classic Remedy, high on atmosphere, and fantastic storytelling. The game left me with the same impression as Alan Wake (though I do favor that game more), where upon finishing it I thought "wow....I won't see that again this Gen." That's a rare feeling, and you can't overvalue that. Uncharted would never engross me the way that QB was able to.
Now Uncharted 4. It's familiar. If I booted it up right now, I know exactly what I'd get. Amazing set pieces, beautiful environments, a good amount of humor. Basically it's a blockbuster. It's fun. And looking at UC4 and the gameplay improvements that ND made, I'm quite certain that I would be a lot more entertained by the second to second play of UC4 than I was by QB, and that's important, because ultimately that enjoyment is what gaming, at it's core is about.
So, I don't know which is better. But I do know, it's not Zelda. Seriously, Zelda games are overrated, and lame.
Thought I was being all diplomatic and shit up until then didn't ya? Suck it Nintendo fans