Even though I don't like the Madden series, this is just too much:
"No multiplayer for 3DS Madden NFL Football
Madden NFL Football 3DS will not include any multiplayer features. This is a major omission from the title, and one of the centre pieces of the Madden series.
In addition, Madden will not include the likes of StreetPass, gyroscopic motion control, or the 3DS' cameras.
Madden is one of the 3DS' launch day titles, but does a complete lack of multiplayer put you off purchasing? "
http://www.3dsfocus.com/2011/02/no-multiplayer-for-3ds-madden-nfl.html
That's right, not even local multyplayer will be avaible, just single player mode.
Above: still the best game of the year.