Some high school boy from an anime vs... POE2 main character.

Considering the POE2 main character kills 1000s in minutes, I don't think I have a chance of survival unless we pose as NPCs.

Homelander has to protect me from Master Chief. My money is on Chief. So, I guess I'm fucked.

The Spider from Spider Noir has to protect me from the MC of Stardew Valley


You know what, imma be fine

Spider Noir, Vs Cloud Strife

I think I'm toast.

Hercules from legendary adventures vs Thomas from suikoden 3.
Iam safe.

Eren Yeager (Attack on Titan) has to protect me from Shulk (Xenoblade Chronicles).

While it would be a cool to see these two fight, I think I'm completely toast. Even if Eren has all of his powers and abilities (Founding Titan and such), Shulk can see the future, has the Monado (can cut anything), has the Monado Arts and at the peak of his power, he can alter the very fabric of the universe at will.

Im ded.

Vs.

Imho, I'm safe.

Rick Sanchez protects me from a Splatling ... I should be fine

I am dead. 

Tony from Who's the Boss must protect me from Ultamondo from Killer is Dead. I am very very dead. 

I have probably the most insane pairing. Carrie Mathison from Homeland must protect me from the engineer of Factorio.

Carrie may have an army of drones with Hellfire rockets to kill everyone at a muslim wedding (literally episode one of season 4) and many CIA informants all over the world, but if she doesn't get the engineer early on the world will be drowned in assemblers building stuff and the pollution will get me ... and everyone else on the world. We are all toast. The engineer will go on to colonize space.