Is this one Mario Kart Double Dash?

You did send me your list but I haven't really looked it through yet, is this Deus Ex?

Gotta add some more hints before I fall too much behind.

#49

- Departure. Initiation. Return.

- A game known for its musical

- When you're not asleep you're _lan ____

#48

- The monster of the Land

#47

- The blue dog got its own game, though it was passed over for a leading role in the movie

(^Both these two are Pokémon games)

#46

- It's TV time! Better turn on the Midnight Channel

#49: Alan Wake 2 

#46: Persona 4

#49

Change YoY: -3  My Rating: 9.1 / 10

Very few games have ever caught my eye in a way that Okami did when I first saw it. There simply wasn't, and still really aren't, any other games that look like it. The watercolours-in-motion look was entirely its own, and a gorgeous one at that. Obviously, beautiful visuals aren't enough by themselves, but fortunately there's a great game to go along with them. As far as games of its kind go (ones inspired by The Legend of Zelda that is), Okami is easily one of the very best ever made. Outside of the game's beautiful visual style, the true standout element of the game is the Celestial Brush, essentially the ability for the player to draw things on top of the gameplay and make various items pop into existence and cause all kinds of other effect to occur. It's the one thing that truly makes Okami unique. In addition, the setting inspired by Japanese folklore is wonderful, not just in terms of its appearance but also in other aspects such as the game's music.

Of course, the game is not perfect, but the faults it has are relatively small all things considered. It is a very long game for one, perhaps a bit too long. The clearest example of this is in just how many of the bosses are repeated over the course of the game. If there was an element of added challenge to these repeated encounters it wouldn't matter, but the bosses are in a lot of ways akin to puzzles for the player to solve, and once you've beaten a boss once it's literally the exact same thing again. Essentially, it become nothing but a time sink, and makes the final dungeon of the game particularly annoying. Otherwise, the game throws in interesting new locations, characters, and abilities at you frequently enough so that it never gets dull to play. The character voices can also get a bit grating at times, and some other minor aspects may not have aged without issue either, but overall this is still an excellent game. The positives basically far outweigh the negatives here.

Both correct!

Wasn't expecting this one to be this difficult. 

#47

• Nexus...
• ...binds the northern lands together...
• ...and ties the souls of all would-be demon hunters so they cannot leave.
• There are six archstones in the nexus, but only five of them are intact, the sixth one being shattered and unusable.
• On the topmost level of the nexus, one can find the only remaining Monumental.

Correct for both of you guys!

Still only 2 games found? Next round of hints then...

#50: Probably the best PC-exclusive fighting game there is.

1. Giants robots are duking it out
2. In the story mode, you can level up both your pilot and machine independently

#49: Unlike in the other games of the series, no transformations here. Shantae and the Pirate's Curse, found by Darashiva

1. Instead of transformations, you got stereotypical pirate equipment
2. The player's main attack is whipping her hair, though a powerful kick can be learned later, plus some more equipment-based attacks.

#48: Looks a lot like Metroid, but isn't Metroid

1. Originally released on the venerable C64, though ports to other machines followed very quickly
2. The Original came out in 1990 and really pushed the C64 to it's limits. Apaprt from the gameplay, it's fondly remembered for it's soundtrack.

#46: Ever wanted to shoot your console? In this game, you can in the final level.

1. A Sega game where you can meet characters like Sonic, Alex Kidd or Samba de Amigo
2. The game id for the most part a simulation with RPG combat, though instead of actually fighting you insult or encourage the enemies you encounter in dungeons.

#44: Lead your people from the Stone Age to the Space Age.

49 is a Shantae game, but I've only played the first one, so maybe Pirate's Curse just going by the name.