This one is the one that I remember oh so well - and not in a good way.
Fallout 3 launched and, while enjoyable and fairly solid RPG, it was a pretty shoddy Fallout game. FO1/2 are some of my all-time favourites, and it was painful to see what Bethesda did with the IP.
But there were some other good sequels/"sequels" - Fable II, Tomb Raider Underworld, Mario Kart Wii, LEGO: Indiana Jones and LEGO: Batman.
Also start of plenty of great new IPs - Mirror's Edge, Left4Dead, Little Big Planet, Dead Space, Mount & Blade.
Two games stood out for me that year - SPORE, another Will Wright's life simulation game, taking you all the way from single cell organism to galactic civilization with what is, basically, five games in one tied all together (though the last, galactic, being a bit overwhelming), While I like most of his games, I consider SPORE to be in his top 3, along with SimCity and Sims. This one is my favourite from that year.
The other one was Braid - not only it was a superb puzzle platformer with fantastic aesthetics, but it is, arguably, THE game the started the whole indie revolution, so my vote goes to Other: Braid.