I have to vote for Mirror's Edge, just love the style and the flow of the gameplay. It is one of my all time favorite games.
GTA IV comes really close for me, it is a game that has grown a lot on me over the years, despite initially disappointing me. It really shows how sometimes less is more. It is smaller than San Andreas and V, but it packs so much detail and character into it's smaller World that it is hard not to love. It is my favorite GTA, even if SA comes close.
Also a huge honorable mention to Gears of War 2, which imo did what the original did, but better in every way. Still the best in the series, I thought the third game was a rather disappointing follow-up. MGS IV is brilliant as well, and I am ashamed I haven't played Fallout 3 or Dead Space yet. Braid was a masterpiece as well, what a year!
Or, well, there were also some terrible ones too. Burnout Paradise abandoned everything great about the Burnout series and suffers severely from Open Worldtidis. Resistance 2 is one of the most generic shooters I have ever played and a disgraceful follow-up to the decent original.
Mario Kart Wii is one of the worst designed games to ever come out of the big N, I have never seen a game punish the player so much for being good. Getting hit by 4-5 blue shells in a single race is not uncommon in Mario Kart Wii, and both the blue shell and red shells stop you completely for seconds. Expanding the number of karts in a race to 12 was clearly an afterthought as the game is not balanced for that. Besides, the drifting sucks compared to previous games. A chaotic, luck-based mess. They even forgot to balance the karts vs bikes. Bikes are just objectively better.