Yep that's the one

17 - Resident Evil 4
- Blue is out, yellow is in, green and red remain.
- Green, red and blue are the available colours of a certain treasure in the game (ordered in value, from low to high), which you will mainly find by defeating insect-like enemies.
- At one point, these insect-like enemies re-kidnap the person you are trying to rescue, who is the child of a very powerful person.

16 - Yoshi's Woolly World (incorrect guesses - Sonic the Hedgehog)
- When our hero starts running at full speed, his legs turn to wheels
- This game was ported from a home console to a handheld system, with the title of the port adding the name of another character in the game.
- This character has the same name as an unpopular addition to a fictional cartoon series that is featured in a long-running animated TV show.

15
- The colour of a character that joins your party is determined by how much time elapses between two in-game events.
- You also get to name this character yourself, who joins your party during the glitz and glamour of the third chapter.

14
- The shape of the item / power up that gives you flight in this game is more commonly associated with completing an objective or invincibility.


Current list - https://gamrconnect.vgchartz.com/thread/247804/the-official-thread-the-14th-annual-greatest-games-event-post-only-once/4/#3

#17: Resident Evil 4

#16: Part of the hint refers to Poochie in Itchy and Scratchy but I can't figure out the game from that.

Because of TruckOSaurus's added 'hint'; Yoshi's Woolly World

These two remain, time for another hint;

13: Spend your Magic Potion strategically.
Hint 2: Though each of your regions needs at least one, it's a better idea to distribute it all along your border. Guessed by Darashiva - Astérix (Asterix: The Gallic Wars)

11: The big nuisance in each level of this game is also a shooting mini-game.
Hint 2: In the regular levels, the holes that spawn the individual nuisances can be 'deleted' by placing something in front of it and removing it again. It's probably a glitch.

13: Asterix. I think it went by a few different names, but the strategy game on PS1.

Resident Evil 4 is correct (first clue refers to herbs, second to Novistador eyes).

And the Poochie part was absolutely correct (given your username, I guess I shouldn't be surprised you got a Simpsons reference), which led to @s.Peelman swooping in and guessing correctly with Yoshi's Woolly World (which was ported from the Wii U to the 3DS as Poochy & Yoshi's Woolly World).

Correct!

As far as I know, it went by two different names. Just 'Asterix', which has a variant 'Astérix' depending on language if you want to count that, and 'Asterix: The Gallic Wars'.

#23
Packed in with a very hungry companion
Finish the whole game and you will see a lot more of yourself
Red marks a secret exit

#20
Pattern recognition hidden as a sports title
McDonalds most famous burger shrinked

#19
Two worlds, two leagues and a legend waiting in the mountains

#18
Previously our hero transformed into a rabbit, something probably viewed as prey now

#17
Turning one of the most boring professions into an absolute blast

#16
Keeping the style of the previous two titles unlike the next installment on the DS

#15
The second time around to experience all he crap people create on order to find a few great

#14
The first one here but still a prequal to #12

#13
Probably the most intense intro ever

#12
Never came but we can sort of thank #46 that at least #12 did

#11
Feature the best two battle modes in the series never to be seen again

16) Could be Pokémon FireRed and LeafGreen?

15) Mario Maker 2?

14) So had to look up your 46 ofc, since it's Melee this would be the first Fire Emblem in the west (the GBA one)

12) Whichever Fire Emblem the GBA one is a prequel to