Alright, lets keep 'em coming

49.-

Hint 1: This game's kind of underwhelming 3rd act almost completely erases the amazing 2nd act it had. 
Hint 2: The Switch version released with aditional content, incluiding a 2D mode. 

47.- 

Hint 1: This is probably the first game you think of when you remember the NES

46.- 

Hint 1: “Annoying bird. I am the great Leon!”

45.-

Hint 1: This one is gonna be a bit vague - The main protagonist's name is usually abbreviated to a single letter.

47: Well the first game I think of is The Adventures of Bayou Billy but, I’m gonna guess Super Mario Bros.

46: Star Fox 64

That’s a no to both. Star Fox though is mostly situated in the same type of environment.

Dragon Quest XI

#49 Dragon Quest XI

Damn I got one-uped.

47.- Its almost Super Mario Bros

46.- Yep, thats the one. 

Correct!

My next game is like my last one, except with a number.

Heh I was actually doubting if I should say SMB or SMB3, so I guess then, Super Mario Bros. 3.

And Star Fox 64 is a treasure trove of one-liners.

#47

Super Smash Bros. Ultimate (Switch)

YoY: -1

The latest entry in what is probably my favourite multiplayer series ever. I don't really even want to think about how many hours I've spent playing the various different Smash Bros. games, but it's literally in the thousands. Whichever was at the time the newest game was, for a period of about 15 or so years, the go-to game my friends and I would almost always play whenever we got together, and for a lot of that period that meant we would play Smash several hours a day, at least four or five days a week.

#46

Super Metroid (SNES)

YoY: -1

This is another game I can't really say anything that hasn't already been said countless times by other people. Super Metroid is not only one of the absolute best games of its generation, it's also still, 27 years after its release, among the best games in the genre it practically created, or at the very least popularized. A beautifully atmospheric title whose impact is still felt in the industry today. 

#44 - Hint: This game is a quest to a place named like a geometric dragon.
Supplementary Hint: The two pyramids are a bit smaller than they used to be, and aren't really pyramids anymore.

#43 - Hint: There are many many ways to die in this game. Drowning, Electrocution, Burning to death, Starvation. Fun for your whole family.