Here's some hints from a couple more of my games.

40.  Part of the gameplay of this game involves obtaining 3 keys to open up 3 different gates.  Kinda like the plot to Ready Player One.

39.  This gameplay on this SNES entry is closer the to the original arcade version of the series than it is to the NES entry.

hmmmm

#42 - The gameplay begins with your character being thrown in an alley and dropping a line that has since become a very popular meme.
Hint 2 - It was the most popular game in this extremely popular series, until being dethroned by one of the best ever selling games.

#41 - This sequel introduced a co-op mode that was the very definition of giving a controller to your younger sibling just so they can feel like they're doing something.
Hint 2 - It's a platformer and it's not Super Mario Galaxy 2.

39) Baldur's Gate III?

Here's the next set of hints so I can stay ahead of the list.

#40

-The immortal main character has no memory of his past life

#39

-The most overrated game I've played from the last five years. Still great though, obviously.

#38

-The 12th game in the series, the 7th game in the sub-series within the series, and the 2nd game in its own story arc within the sub-series

#37

-A helicopter makes a building collapse while you're inside it

#36

-Eventually, there will be a singularity where all the video game characters ever will have appeared in this series. This is the latest entry.

Here's the next set of hints so I can stay ahead of the list.

#40

-The immortal main character has no memory of his past life

#39

-The most overrated game I've played from the last five years. Still great though, obviously.

#38

-The 12th game in the series, the 7th game in the sub-series within the series, and the 2nd game in its own story arc within the sub-series

#37

-A helicopter makes a building collapse while you're inside it

#36

-Eventually, there will be a singularity where all the video game characters ever will have appeared in this series. This is the latest entry.

#39: Zelda: Breath of the Wild

#36: Super Smash Bros Ultimate

39 - Thats either BOTW or Mario Odyssey. Since BOTW is taken, im going with Mario Odyssey. 

37 - Uncharted 2 

42 is right, 41 isn't.

I guess it's time for the next bunch of games to guess.

#39: Baldur's Gate III guessed by UnderwaterFunktown
After 20 years finally we get the third mainline entry, for the moment in early access.

#38
Your spaceship crashed on this strange planet and you need to find it's missing parts.

#37
Your first task: dig out a skull.

38: Pikmin?