I can't really say who is the best actor or actress as some actors have completely different styles and roles. There for comparing Adam Sandler to Matt Damon would just not work because Adam Sandler excels in Comedy where as Matt Damon is a diverse actor etc.
Anyways I'd take Angelina Jolie for her diversity
Salt
A Mighty Heart
Kung Fu Panda
Mr & Mrs Smith
Changeling
Lara Croft
Sandra Bullock and Julia Roberts are also amazing actresses themselves.
As an actor I'd take Leonardo DiCaprio. Everything he is in he accels in.
Django Unchained
The Departed
Titanic
What's Eating Gilbert Grape
Catch me if you can
Inception
Blood Diamond
Shutter Island
Other great actors that i had in mind was Tom Hanks, Will Smith, and Matt Damon.
Anyways what are your alls favorites?