God of War III - 8 or 9 playthroughs, can't remember which. I'll play it a couple more times before God of War IV.

That said, I've gone back to play through certain moments at least 150 times, I must've killed Cronos at least 30 times... Just so epic. 

Pokemon Red/Blue - at least 20 times (and 2 more if you count the remakes too)

Excluding Dynasty Warriors 5 and its dozens of characters and short campaigns, I would have to say MGS2 or MGS4. I've completed MGS4 what, 8 times now I think? That said, it feels like I've played MGS2 more than that but I'm really not sure.

When I was like 8 and first had Ocarina of Time, I couldn't stop playing. Not necessarily one play through after another (Though some were), but I probably played it over 10 times through for sure at the LEAST.

Will have to go with Diablo 2. Really have no idea how many times I have played through this game!! Easily more then 100times lol.

Second will go to Crash bandicoot 3 and third to Muppet RaceMania.

I've completed Super Metroid over fifteen times (five 100% runs), I've played through the Warcraft III campaign from start to finish on an annual basis for the last decade (probably twice in some years), and I've blazed through Lylat Wars at least a quarter-hundred times. Other big ones include Super Mario Bros. 3, Sonic & Knuckles, Metal Slug 2/X and Ratchet & Clank 2. Five times each.

I don't think that's too bad, considering that most of you have more than four years on me.

Haha I hear you;

I've probably beat Poseidon, Hades, Cronos and Hercules over like 20 times each xD.

Halo:CE- can't tell you how many times exactly, but I would say over 25 for sure.
Halo 2-Probably 20 or more
Halo 3- Probably 10
LOTR: Return of the King-10
Pokemon Gold-5
Halo Reach-4
ME2-3
Alan Wake-3

Getting XBL in 2008 killed off a lot of that multi-playthroughs. Why replay through something like Halo Reach when I've already beat everything and there is awesome multiplayer I could spend hundreds of hours on instead?

Resident Evil 4 gcn - 15 times on one save file, 6 on another, 3 on the last

TruckOSaurus said: I'm so surprised by your number one game Aldro Mine is probably Mega Man 2 with god knows how many times. It's a really short game when you know it inside out and back then I played all my games to death (since I didn't have my own money to buy new games by myself).

omg i believe mine is mega man 2 as well! but to be honest i play videogames for over 20 years now and i've played through hundreds of them but even when i love a game i really don't play through it more than maybe 5 times. mega man 2 maybe 10 times.

even the best gaming experience is getting boring for me after few playthroughs even as gaming addicted (ok not addicted but, you know...)