Samus can survive a grenade blast.
Samus is pretty close to invincible with her "Screw Attack".
Samus can run at super speed.
Samus has a different beam weapon for any situation and can charge these beams if necessary.
Samus is a master at using anything in the environment to accomplish her means.
Samus can go into "Hyper Mode" that makes her even more deadly.
Samus can practically fly using her "space jump".
Samus can roll into a ball that has incredible maneuverability and can still attack.
Samus has different visor modes that can allow her to see/analyze her enemy and their weaknesses
Samus is a woman. Whenever a man faces a woman, the woman wins. She'll spend all of Masterchief's money, make fun of his penis to her girlfriends, and make him mow the lawn when he wants to play Final Fantasy 13.
Master Chief is pretty normal aside from his training, mental resolve, and armor.