Here are some more hints from me:
45. a) Overall I prefer the more linear games from this series, but I decided to remove "Bloodlines" from my list to make room for this game.
44. a) I discovered this digital only tower defense game on the PS3 while I was waiting for some fun physical games to be released.
42. a) I've always loved this PS3 sequel, but previously I didn't put it on my list. I've considered it to be fairly similar to the first entry in the series which is much higher on my list. Maybe the fact that the first game is now on Switch made me change my mind.
41. This is a more kid friendly GBA sequel to a PS1 game with a more serious storyline.
#44 is the PixelJunk series. Tower Defense must be PixelJunk Monsters.