Hardware designs don't really stop a game from "breaking out" ... case in point, the Game Boy was almost 2 feet in its grave before Pokemon came out nowhere to reignite the platform.
Same thing with Monster Hunter on PSP, it looked like the DS was going to trouce it, but in Japan MH gave the PSP life. Even the DS, before Brain Training things were not going well at all.
The issue with Switch I'm not really seeing the game idea here that's going to drive hardware sales to a monumental level. There's no Wii Sports kind of *new* idea that looks like it could draw millions of new people. 1,2 Switch is the same tired mini-game Wario Ware mini-games idea. In 10 years Nintendo has not really evolved the idea of "casual gaming" beyond the same "wave your arms around for 2 minutes, it's hillarious!" mini-game concept.
Splatoon is great for Japan, but in North America or Europe, Splatoon really did not boost Wii U hardware sales.
Super Mario Odyessy looks cool, that said it's returning to a more open-world Mario style, which is nice, but Mario Sunshine I remember had a ton of pressure on it to sell GameCubes and it couldn't get the job done.
ARMS looks neat, maybe that can break out, but I'm not sure, I was actually surprised that Game Xplain said that the game actually has a fairly steep learning curve. Mario Kart 8 is a port of a 2 year old game that millions of people have already played.
Like saying you're going to "break out" and capture this new audience is all fine and dandy, it's like a person saying they're going to become a big-time model ... without the looks to go with it. That's kind of a problem.
From what Nintendo showed, I saw a lot of great Nintendo games, but the GameCube and Wii U also had a lot of great Nintendo games, in Wii U's case it had a lot of these same or similar games.