1. Phoenix Wright series
2. Braid and Trine (tied)
3. Phantasy Star IV on the PS3 (Sonic Ultimate Genesis Collection) :P
4. Uncharted 2
5. Bayonetta
6. Ninja Gaiden Sigma 2
7. Siren: Blood Curse
8. Katamari Forever
9. Cooking Mama
10. Persona Portable/Star Ocean: First Departure

Excluding DS and PSP games.

1. No More Heroes
2. Ace Combat 6 with Flight Stick
3. Mario Galaxy
4. New Super Mario Bros Wii
5. Mario Kart Wii
6. Demon Souls
7. Call of Duty 4: Modern Warfare
8. Uncharted 2
9. Call of Duty Modern Warfare 2
10. Assassin Creed Franchise (Yes I lump 1 and 2 together)

Edit: Tales of Vesperia should be in there...guess between Mario Kart Wii and Demon Souls. 

10- Call of Duty 4 Modern Warfare
9- Punch-Out
8- Resistance: Fall of Man
7- Resident Evil 5
6- Street Fighter IV
5- Valkyria Chronicles/ Demon's Souls
4- Assassin's Creed II
3- Metal Gear Solid 4: Guns of the Patriots
2- Halo 3 (*online multiplayer)
1- Assassin's Creed

10.Folklore
09.Devil May Cry 4
08.Little Big Planet
07.Assassin 's Creed 2
06 Dissidia
05.MGS4
04.Resident Evil 5
03. Naruto Ultimate Ninja Strom
02.Eternal Sonata
01.VALKYRIA CHRONICLES

1. Zelda: Tp
2. NSMBwii
3. M & L: Bowesr's inside story
4. Silent Hill: Shattered Memories
5. Mario Galaxy
that's enough for me...

VALKYRIA CHRONICLES reminds me of TANK POLICE ^_^

10. Uncharted
9. Gears of War
8. Demon Souls
7. The Witcher PC
6. Oblivion
5. Uncharted 2
4. Lost Odyssey
3. Dragon Age PC
2. Mass Effect Xbox 360
1. Metal Gear Solid IV

1. Fallout 3
2. Assassin's Creed II
3. Gears of War 2
4. Call of Duty: Modern Warfare 2
5. Orange Box
6. Assassin's Creed
7. Gears of War
8. Call of Duty 4: Modern Warfare
9. Resident Evil 5
10.Halo 3

Honorable mentions: Resistance 2, BioShock, Elder Scrolls IV: Oblivion, Valkyria Chronicles, Project Gotham Racing 4

10. HD TV gaming
9. Introduced me to the FPS
8. Introduced me to the RPG
7. PS3's PSone library gave me the chance to play FF VII and other classics
6. PS2 backward compatibility introduced me to playstation
5. Motion controls
4. Online gaming
3. Playstation network store, and features
2. ?!@#^ gaphics?
1. Metal gear solid IV : never have I cried as much as I did in a game, never had I ever been emotionally involved as much in a gaming experience, truely by far the best gaming experience I have had in my life till this date.

I can't tell you an order but it's some form of these:

DJ Hero
MP3: Corruption
Wii Sports (I'm tell you it's an aphrodisiac, and no one believes me)
Brawl
Kart
Half-Life 2
Portal
World of Goo
Civilization 4

The Witcher

I know it's not 10 on there, but I can't think of too many other games that were worthwhile this gen.

Edit: Forgot about The Witcher, that should make it 10.