Ohh ball shots ... Sniper Elite V2 I think it was, very early in the game I got a shot on an enemies gonads. Bullet time x-ray of his jewels exploding .... spent way more time than I should have trying to recreate that shot. I do not recall being successful though.

I always though Uncharted 4 was dark. I mean in the first games, Nate is killing pirates and legit bad people. While in UC4, Drake kills a ton of people who have permits and are actively doing their work. Drake, in many ways, feels like the bad guy in UC4.

I mean in UC1-3, Drake is stopping someone from world domination, while in UC4 he is killing people for gold...  never sat right with me, still love the game. but felt weak.  

My strong opinion would be Amy Hennig leaving ND was a huge lose.  UC1-3 and TLoU had great stories.  Since she left UC4 and TLoU2 had massive drops in their respective stories.

I feel bad killing certain creatures in Metroid Prime if they're not hurting me. Some of them are just minding their own business.

Yeah the kill shots can be spectacularly gruesome in Sniper Elite 3 and 4; even though they're Nazis, I winced a few times and felt like a bastard when I splattered their nads or ruptured a lung.