GTA V probably, or a COD. This is the single best opportunity for a game to do this though in terms of timing and hype etc.
There's only 2 races: White and 'Political Agenda'
2 Genders: Male and 'Political Agenda'
2 Hairstyles for female characters: Long and 'Political Agenda'
2 Sexualities: Straight and 'Political Agenda'