Some more hints
45. Some say it's a Zelda for 18+ ||| Darksiders ||| guessed by Mnementh
44. a) The main character has to take back his own castle from an evil relative.
b) This game is part of a very very popular franchise
43. a) In this game, Audie seems to be a tribute to a real person
b) Audie is a wolf
42. This game is the first in the serie's timeline ||| The Legend of Zelda: Skyward Sword ||| guessed by The_Liquid_Laser
41. a) Living together in peace, the inhabitants of an island are always full of joy thanks to a tree. But everything is taken away
b) The tree is stolen, and one inhabitant, of desired color, has to go through a 6 pages Storybook to get it back.