They have already announced some of their plans to reduce the affect of griefing from player killers. For starters, unlike similar online survival games like Rust and DayZ, your progression isn't reset when you die and you don't lose all of your items, just some of the money you're carrying I believe. From what I've heard, if your settlement gets destroyed by other players, you don't have to rebuild from scratch, you can save settlement designs and easily rebuild them. Todd also insinuated in one interview that there might only be certain areas of the map where PvP is possible, so there might be some safe zones you can explore and build settlements in. Other than that, all he said is that they're working on other ways to incentive co-op play over PvP play.
I've seen people worried about their base or themselves getting nuked by other players, but the truth is it's not something you really have to worry about. You need a set of 5 codes to activate a nuke and apparently it is very difficult to get all 5 solo, which basically means 5 total strangers with codes have to group up instead of killing each other, and even if they do launch a nuke it affects only around 2% of the game map, so there is only about a 2% chance you'll be caught in the blast radius.Last edited by shikamaru317 - on 15 June 2018