Sony and Nintendo are going to battle it out. I think Microsoft will ultimately be the loser due to the focus on scorpio alone. Sure it's powerful but it needs to bring the games. I'd like to have faith in Phil and I do to some extent but I don't think Xbox is up to the task for this E3. I hope to be proven wrong though as a success for them is a success for the entire industry.
I'm sure Sony is gonna bring out its heavy artillery, FFVII Remake, Crash Trilogy, ...Knack 2...Death Stranding, Detroit, GOW IV,etc. etc. in addition to the multiplats.
Nintendo, I'm sure they're gonna have some wild cards here and there but Arms, Mario Odyssey, Splatoon 2, Fire Emblem Warriors, Xenoblade Chronicles 2, and some surprises should sprinkle their presentation. Aonuma did say he'd like to work on a new project so maybe we'll see something from that. In addition to the few multiplats it will receive.
I think Nintendo has the best chance to shine because you know...new platform and all. And the first real 3D Mario in a little under a decade. One thing is for certain, this E3 will be one for the history books I think.