Lair 2. Lair 1 looked AMAZING and that was less than 1 year into the ps3s release. I haven't played or even seen much of Lair 2 (if any at all) but I think the gamers will learn from their mistake and learn to use the motion controls. Also Lair 2 will have rumble!!!

 IS factor 5 going to make Lair 2? Didn't sony kick them to the curb after lair bombed, or they left?

I think that it will be MGS4 :D

MGS4, GTA4, GoW2, Spore, Starcraft 2,

Wii Fit

GTA4 for the easy win

My top 3 Guesses:

1. Metal Gear Solid 4 (PS3)

2. Super Smash bros brawl (Wii)

3. Grand Theft Auto 4 (PS3/360)

Metal Gear Solid 4, Spore or Gears of War 2.

I'm going with GTA4 it's going to be either that or MGS4.

GOTY isn't just about the "game" per se. But there are a lot of other factors: hype, if it lived up to the hype, exceeded the hype, etc.

Actually throw Gears 2 in there, Bank on it for one of those 3 but if I had to put money down right now (which I wouldn't because we haven't even SEEN Gears 2 or other games). I'd go with GTA4 all off of the impressions on what they did to make the series BETTER from kotaku's hands on with it

i'll name one game from each console that i think will deserve.
wii..super smash bros. brawl
ps3. mgs4 guns of the patriots
x360. gears of war 2