Animal crossing.
Something from Retro.
More mobile games coming to their consoles.
Project treasure.
Gamepadless wii u, hardware revision, huge price cut, ambassador program.

Please be Metroid

I'd settle for Sega/Atlus (both small companies, doubtful anyone would have to lose their job), Konami (they are putting themselves out of business, whoever gets fired in that process is likely to get fired in the next year or two anyways), and Capcom (because I am just way too interested in seeing what a company far less currupted by the almighty dollar would do with Capcom's IPs). 

>be me, watching Nintendo's E3 direct
>get bored from all the Mario Maker and Yoshi crap at the start
>suddenly, screen is black, no sound
>robotic voice starts a countdown from 3
>F-Zero UX appears on screen
>Infinite Blue starts playing
>all 30 racers are in a tunnel
>bright light at the end
>players exit the tunnel, greeted by a beautiful sunrise over the ocean in 1080p 60fps in perfect timing with the music
>**2sexy4vgcstuff**
>**2sexy4vgcstuff**

>i wake up late for the direct with bed covered in all sorts on bodily fluids
>mfw dreams don't come true

I'm expecting:

- New Infos or/and Trailers from at least 6 of the 9 Wii U games still scheduled for this year, plus exact release dates for 2 or 3 of them
- Paper Mario (development of a new paper mario had been leaked last year)
- Showcase of some interesting Indie Titles coming to the Wii U
- Project Guard getting released right after the presentation (it did show up in Nintendos annual report a few days ago as 1st half 2015, don't see any better opportunity in that timeframe to release the game than this)
- Next Amiibo Series

Less probable, but still possible:

- Pokkén Fighters U
- Metroid
- F-Zero U (as long as they don't call it F-U...)
- Maybe some third party game (Unless they're Indies or exclusives, third party titles tend to not show up Nintendo Direct, but Project Treasure might do so)
- SNES Remix
- Some Mario Sports title (Mario Strikers/Smash Football, Mario Sluggers, etc...

Dream: Cross platform, cross-brand Smash Bros.

Reality: Vague discussion on NX that will give no new information whatsoever.

Here are my predictions (which are clearly valid and proven true countless times):

Wii U:
-Animal Crossing U for 2015 holiday
-Paper Mario U trailer, 2016 release
-Metroid teaser (no gameplay) set for late 2016
-Pokken Fighters Wii U
-Xenoblade X release date finally announced
-Star Fox gameplay and release window
-Fatal Frame information, possibly Fatal Frame IV bundled with V
-New account system revealed
-Remake from the GameCube

3DS:
-New retail Pokemon spinoff (likely the Pikachu detective game)
-Bravely Second, Rhythm Heaven and Ace Attorney localization trailers
-Regular New 3DS announced for NA
-New IP for 3DS
-Metroid 3DS gameplay
-More Kirby announced

Edit: OH, and SMTxFE trailer with release window for the West (likely mid-2016)

Don't forget:

- Wonderful 101 and Pikmin 3 were announced for Wii U's launch window, arrived second half of 2013.

- Wii Fit U and Wii Party U were delayed.

- Captain Toad delayed by a month in PAL.

- Kirby & The Rainbow Curse delayed by nearly 3 months in PAL.

- Tropical Freeze pushed back 3 months.

So yeah, I'd be utterly unsurprised if Starfox is pushed back to 2016. Nintendo is addicted to delays.

-Paper Mario U
-Metroid
-Star Fox info
-Animal Crossing U
-Pokemon Z
-Pokken Fighters
-A real 3D Mario (please)
-probably a remake
-GameCube games for the virtual console
-Reggie becomes the king of the world

What I want:

METROID.

What will happen:

ANYTHING BUT METROID. But there will most likely be Paper Mario, Animal Crossing, and definitely Star Fox.