NO!

Neither mouse nor keyboard is the best. I'd probably pick the 360 controller as best followed by PS3 controller, followed by keyboard/mouse, followed by Wiimote

 have you ever played a PC game before? and I mean a good PC game like Half-Life, World of Warcraft, Warcraft, Diablo, Battlefield, NfS, Final Fantasy 11, Gunz the Duels, AudioSuft?

the only genre I have found that console controllers works better at is fighting. Even then its questionable.

In general the expansive ability of a computer give a huge edge over any system, after an initial purchase a simple and low cost occasional upgrade keeps it on the graphical edge, and the mouse seems to still allow the most comfort and agility needed in nearly all geanras, though racing and fighting should be controlled with a gamepad, RTSs, FPSs, MMOs, RPGs(in general benefit better with mouse controls) though can be tooled to work with a controller and so forth...... though this is my opinion and a general PC gamer with consoles ont he side like an Xbox and Wii...

that's what I mean, the wiimote is great and all, but it just can't do the same things as a mouse and keyboard, in fact, no gaming controller can. and the M & KB can't do some of the things controllers can but it destroy's controllers when it comes to FPS's.

3 examples:

1. Battlefield (series)

2. Call of duty(series)

3. F.E.A.R  (series)

4 games you can compare:

1.Call of Duty 2 (on PC and x360)

2. Battlefield 2 and battlefield modern combat (on PC, x360, ps2, xbox)

3. F.E.A.R (on PC, x360, ps3)

4. Far Cry (on PC, x360, wii, Xbox)

It's easy if you have a small bounding box. If you're facing an enemy, move forward and to the left. You'll have to move your targeting cursor to the right to keep aiming at the enemy, causing your camera to start turning to the right. Tah dah! You're circle strafing.

Mouse+Keyboard is the best for FPS, RTS, and adventure games.

Good thing I have a gamepad, joystick, and racing wheel for my PC. lol

M & K = best for FPS, RTS and any game where pinpoint accuracy of a 'point and click' nature is key to the game. I've been playing more and more FPS on consoles, and its certainly ok, but the input precision simply can't match K & M and won't without major redesign.

However, there are many other genres (platforming for one - say something like Ratchet and Clank) where a gamepad is superior, or something like Wii controls for titles like Wii Sports.

My favorite for RTS and certain FPS games.

depends on the game. I'd actually say the dualshock or 360 controller is the most versatile and therefore feels good with most games. the dualshock is great for playing snes roms. kb/m is great for FPS games, and the wiimote is also ok for certain games. I also think the wiimote is basically a prototype for motion/ir controls and a more refined version will surely improve upon the current pitfalls of the wii controller.