Another winner over here.

Armando inspired me in a way very few fictional characters have been able to.

Yup! I get geekbumps when ever I think of that part..

"Heihachi Mishima.... is dead" - Raven (Tekken 5)

Was gonna go with "Fithos, Lusec, Wecos, Vinose" but now I think about it, im not sure if anyone actually says it in the game

Eliza Cassan: It's not the end of the world, but you can see it from here.
Deus Ex: Human Revolution

Elizabeth: Booker, are you afraid of God?
Booker DeWitt: No. But I'm afraid of you.
Bioshock Infinite

Blazkovitch: Jesus Christ Tekla, aren't you asleep?
Tekla: I try not to sleep. No telling if I will ever wake up.
T: Let me ask you something.
T: Where do you go when you loose conciousness?
B: What?
T: You have a brain, a brain is a biological computational device running an electrochemical process.
T: Your conciousness is an emergent property of said process.
T: In other words: you are your electrochemical process.
T: Fundamentally, you have experience of continuous existence.
T: You are you, at this point in time. You have sensation of riding along this continuum of being you, into the future.
T: On occasion brain can be subjected to trauma, temporarily discontinuing the electrochemical process.
T: Such as a boxer being knocked out.
T: As this occurs the brain is no longer running. It's electrochemical, conciusness generating, process.
T: Hence conciousness is lost.
T: You loose conciousness. Pay attention now.
T: At this point in time, your consciousness, all that is you...
T: ...your continuum of being you has ceased to exist in the physical world.
T: Now, moments later, the electrochemical process may start up again...
T: ... allowing consciousness to emerge out of the information stored in the brain.
T: But I wonder. Where are you in the meantime?
T: Must we not assume that at the point when consciousness is lost, the person dies?
T: If a new consciousness appears or not in the same brain is entirely inconsequential to the dead consciousness.
T: The new consciousness is simply a new person.
T: Because it emerges from the same brain it has access to all the memories and cognitive structures as the dead consciousness, so it thinks it is the same person.
T: But in actuality it is just an impostor.
T: Inheriting the body and brain from the previous, now dead, inhabitant.
T: Yes?
B: What about the soul?
T: Soul...
T: There is no such thing as a soul.
T: We are machines of biology.
T: Nothing more, nothing less.
T: The soul is simply a pointless concept dreamt up by priests and fairy tale men.
Wolfenstein - The New Order

Glad0s: The Enrichment Center regrets to inform you that this next test is impossible. Make no attempt to solve it.
Glad0s: [after Chell completes test chamber] Fantastic. You remained resolute and resourceful in an atmosphere of extreme pessimism.
... and basically everything else Glad0s said in Portal

Robert Lutece: I told you they'd come.
Rosalind Lutece: No you didn't.
Robert Lutece: I was GOING to tell you they'd come.
Rosalind Lutece: But you didn't.
Robert Lutece: But I don't.
Rosalind Lutece: You sure that's right?
Robert Lutece: I was going to have told you they'd come.
Rosalind Lutece: No.
Robert Lutece: the subjunctive?
Rosalind Lutece: That's not the subjunctive.
Robert Lutece: I don't think think syntax has being invented yet.
Rosalind Lutece: It would have had to have been.
Robert Lutece: Had to had been? That cant be right.
Bioshock Infinite

Announcer: This is art. You will hear a buzzer. When you hear the buzzer, stare at the art. [BUZZER]
Announcer: [BUZZES AGAIN] You should now feel mentally reinvigorated. If you suspect staring at art has not provided the required intellectual sustenance, reflect briefly on this classical music. [MUSIC INTERRUPTED BY BUZZER]
Portal 2

• Do you sleep still? Wait! Do not be hasty, boy... I can see this girl's dreams... Oceans... Oceans... Oceans... Oceans... Oceans as far as the eye can see. They are vast seas... None can swim across them... They yield no fish to catch... What did the King of Hyrule say? ...That the gods sealed Hyrule away? And they left behind people who would one day awaken Hyrule?! How ridiculous... So many pathetic creatures, scattered across a handful of islands, drifting on this sea like fallen leaves on a forgotten pool... What can they possibly hope to achieve? Don't you see? All of you... Your gods destroyed you! I have been waiting for you, boy. For one like you... Yes... For the hero. Do not betray my expectations.
  
  -Ganondorf (The Legend of Zelda: The Wind Waker)

People talking about Duke Nukem made me think of Shadow Warrior.

It's down to you and me Mr. Fly. - Lo Wang while chopping sticks at fly, Shadow Warrior

"SHUT UP TAILS!!!"

~ Sonic

There are so many

"Today, we use our power to fell a god, and then, seize our destiny!"

Shulk - Xenoblade Chronicles.

"Once a snake has ensnared it's prey, rarely does it release it"

9 persons 9 hours 9 doors

"You misunderstand me. You haven't lost Jumpei. I lost."

9 persons 9 hours 9 doors

"My hate... never perishes. It is born anew in a cycle with no end! I will rise again! Those like you... Those who share the blood of the goddess and the spirit of the hero... They are eternaly bound to this curse. An incarnation of my hatred shall ever follow your kind, dooming them to wander a blood-soaked sea of darkness for all eternity!"

Demise - The legend of Zelda: Skyward Sword

"Worry not, I won't kill you. A well tortured victim doesn't die. At least not before a few months."

Zacrisfal - Blades of Heaven

"I hope this is NOT Chris' blood..."

https://www.youtube.com/watch?v=9oDGBDUKMcc