Not going to name any names, but I'd like to educate or remind some posters in this thread what the definition of a plot hole is:
"A plot hole, or plothole is a gap or inconsistency in a storyline that creates a paradox in the story that cannot be reconciled with any explanation. These include such things as illogical or impossible events, and statements or events that contradict earlier events in the storyline." -Wikipedia
In other words, it's not a plot hole if the characters in the plot made some questionable choices, make cutscene or plot decisions that don't fit with actual gameplay, or the game world defies some real world natural laws or physics. It's only a plot hole if something that happened that logically should have grounded the events to a halt with no possible explanation as to why that event happened.
So for instance, Samus' refusal to use her full arsenal in Metroid: Other M is not a plot hole, because Malkovitch commanded her not to. But poklane's example from Fallout 3 is a plothole, because logically, it would not be possible within the game's world.