The WiiU
OUYA
Xbox One
PS Vita
(Steam machines, maybe!)

The biggest loser will be the gamers. They will be subjected to games devoid of imagination and creativity by studios trying to make the next blockbuster IP. For some reason today's gamers think it's more important to play a game just because others play it. It doesn't matter if it's good or not. When did games become pop music? However, if consumers keep buying it they will keep making it. 

@Fox True. Oh so true. 

Don't believe everything you read on the internet.

Sony has double the equity of Nintendo, and growing.

Nintendo's profits are actually hanging by a thread.  3DS has good revenues, but who knows how long it will maintain this level.  Meanwhile Wii and DS are also still contributing a lot to their revenues.  As the Wii and DS fade away if the Wii U can't fill the void they will start losing cash big time.  Nothing will bankrupt Nintendo any time soon, but they could significantly scale back their position in game consoles.

The biggest losers will naturally be gamers. Why? Here's why:
Nintendo gamers because of Wii U and its slow stream of games
Sony gamers because Vita is doing quite poorly and there's "no gaemz" for it
MS gamers because X1 costs $100 more than the second most expensive console, and kinect (the reason for that extra $100) will largely not be utilized
3rd party gamers because 3rd parties will try to nickel and dime them with crappy dlcs and microtransactions

There you have it, loser.

EA, Capcom, and possibly Microsoft due to their poor pricing. Sony could be in trouble due to Vita, but I think the PS4 will do well, at least for now. Nintendo will be Nintendo and somehow make a profit despite the Wii U's failings.

VITA!!!!!!!!!!!!!!!!

All three console developers are going to have problems this generation.

Nintendo - Where the f**k is the software? The Wii U launch was great (2nd best ever at the time), but to release literally nothing for 8 months is a surefire way to make people lose interest in your console. From August to December we got Pikmin 3 (Niche title), W101 (Super Niche title), Wind Waker HD (Remake), Wii Party U, and finally Super Mario 3D World. Only SM3DW had any potential to move a bunch of consoles, and with the heavy supply of Mario games in the last 6 years, people just are not nearly as hungry to play Mario as they were in 2006. Even if their future lineup boosts their Wii U sales by alot, their peak at this point is no more then 65 - 70 million, and thats only if they give the Wii U a 3DSesque lineup. The 3DS is going good, nothing else to say.

Sony - The lack of 1st party software sold by Sony is disturbing. The 1st party game attach rate on the PS3 is a 1.35, and that's including all the bundled software. Without the bundled software that number may not even be at 1. That would mean that there are millions of PS3 owners out there, who never purchased one brand new 1st party Sony game. To make matters worse, The Vita's entire 1st party lineup has been outsold by Pokemon X/Y...twofold. Unless things change this generation, Sony could sell 100 million PS4's and still easily go broke. This is what happens when 80 percent of your 1st party games can only be played by people older then 18, and when your one game aimed towards everyone (LittleBigPlanet), is focused on level creation and things that most casual gamers couldn't care less about.

Microsoft -  I have alot of mixed feelings about Microsoft this generation.  Part of me thinks that alot of gamers are sick of their garbage (RROD,anti-consumer policies,lack of Kinect support) and will reject it in favor of the PS4, but their is also a part of me that thinks that Sony has little to offer in terms of 1st party games and Titanfall / Halo 5 will be more then enough to get the console ahead of the PS4.    The thing to watch for me is what Microsoft does about the price.  $499 for a video game console is just too much for the average person to spend, expecially with an extra controller, games, and Xbox Live. 

Vita will die first.
then xbox one will die next.

Hard to say.....

.... but I do expect more third party developers to go bankrupt this year, specially western ones.

as for consoles, the WiiU will keep struggling, but the huge sucessfull 3ds will keep nintendo riding the waves. Sony has nothing to complain, the PS4 will be the best seller this generation. I feel worried about Microsoft, its console is not doing so well in Europe and there are no plans for Japan (well, it wouldn´t sell well there anyway), MS has only the Americas to keep their videogame business healthy