My favorite, hands down, is Kirby. The music from that save room in the Cave Offensive in Super Star still gives me goosebumps....  I would buy an XL solely for a Kirby game. And that's coming next year!!!

My favorite games in the Kirby series are in order: Kirby and the Amazing Mirror, Kirby: Super Star, Kirby: Nightmare in Dreamland

My other favorite franchises are of course Mario and Pokemon.

Warioland on the GBA.

Pokemon

The Legend of Zelda, but Pokemon is a pretty close 2nd :)

Donkey Kong or Star Fox OR Pokemon. (Or Kirby)

Zelda.

Endless Ocean! All the joys of scuba diving with out getting cold and wet!

Does Yoshi count?

Pokemon. Most memories, most fun; brings me back to simpler times.

Zelda! No doubt about it! Followed by Mario and Kirby!