Yes!

Bob: (Sounding slightly "dazed")Whoa...man...
Steve: What are you doing?
Bob: Can't you see dude? I'm surfing dude...
Steve: You are sat on the couch in your underwear.
Bob: No dude, I'm like...whoa dude, I'm surfing the music man...can't you feel it?
Steve: You are sat in your pants on my couch!
Bob: No, no, no dude. I can see the music man, I can totally see the colours of the music and I'm like riding on it on my spaceship dude, it's so friggin trippy man...
Steve: Urgh, I swear to god that's the last time I let you eat Blue M&Ms.

44: is AudioSurf!

45. Professor Layton and the Curious Village

There are a lot of puzzle games on the DS, and they probably played a decent part in its success, but few of them tried anything like Level-5 did with this series, with a story wrapped around a collection of puzzles. It worked extremely well, and is one of the standout new IPs that I've played in the last five years.

My 44th game is part of a now seemingly dormant franchise that spawned quite a few memorable quotes, one of which in particular found its way into a mainstream arena relatively recently.

Alright, my 44 is...!

Star Fox Adventures (GC)

I know a lot of people didn't like it nearly as much as the games that came before or after, but I actually had a really good time playing it. Even if there were some repetitive moments, exploring the world was one of my favorite past-times. Also, at the time, I remember thinking it was one of the prettiest games I'd ever fired up on the Gamecube. I really should hurry up and give Star Fox Assault a playthrough as well, one of these days...

#43 Hint (Edit, realized I was looking at the wrong game, my bad): Considered one of the weaker entries in this long-running RPG franchise, it's still a very fun game in its own right. Also the first in the series where you could actually run... 

43:
* Boom!*
Voiceover: AGAIN! 
*Mechanical whirling*
*rapid  thudding noise*
Voiceover: PPPPPPPPPPPPPPPPPPPPPPUUUUUUUUUUUUUUURRRRRRRRRFFFFFFFFECT!
*Angellic Chorus* 
Steve: What the hell is going on?!
Bob: Oh hi steve. I'm doing an IQ test.
Steve: What kind of IQ test are you doing?
Bob: An incredibly awesome one to show how smart I am!
Steve: You? Smart? What the hell?
Bob: Yup, I have an IQ of 271! :D
Steve: Bullcrap!
Bob: Look.
Steve: 271...? That's a lie and you know it!

My 43 game is related to pipes

45. Final Fantasy X-2 (2003)

Dropping from 26; I don't think I've ever simultaneously enjoyed and hated a game so much at the same time as while playing this game.  Let's get the formalities out of the way; story, characters and annoyingly long dress sphere changes were a disappointment compared to X.  Fortunately, the gameplay was wonderful.  Once again having the ability to choose your characters class was a major plus and adding in that you could customize how you switched between them in battle was fascinating.  The faster paced battle system that I usually dislike seemed to fit right in as well.  On top of that the airship hub which allowed you to travel where you want and create opportunities for exploration of a different side of the world from X was enjoyable.  Finally, they catered to my obsessive nature with a completion percentage for choosing different paths through the game, which is something I probably shouldn't but celebrating.

You are my hero. Star Fox Adventures is a really good game that gets dumped on far too frequently. And it's definitely one of the prettiest games on the Gamecube...those water and fur effects!

My 45 - Street fighter EX plus Alpha - Playstation 1

Street fighters first (afaik) flurry into 3d on the playstation one. Made by arika tho along with capcom so unfortunately the characters created for this game by Arika were lost from street fighter after they went seperate ways, this is a shame considering that D.Dark and Garuda are 2 incredibly well put together characters for street fighter, ,D.Dark even able to lay mines in the ground then whip his enemies into them with a scorpion style rope attack. While the polygons again seen here are at a countable lvl the game moves so smoothly when you get into fighting it is easy to over look the basic character models when it's game engine is absolutely great.

btw dieappledie I can finish your number 48 in a single credit in the arcades :D it appears further up my list.

my 44 is a game that was a nintendo new IP on the gamecube and based on the ongoings in Miyamotas backgarden.... in his head.