Lots of excellent suggestions here already.
There are numerous titles with co-op play like all the Lego titles, Ghostbusters, and many more.
Sports titles of all sorts: NBA Jam, Tiger Woods ('10 or later), Madden, FIFA (I perfer 09 'cause it still has with Miis for non-serious players), PES (different play style than HD consoles, using IR to direct whole team). MLB or Power Pros
Mario Sports: Strikers (excellent), Tennis, Sports Mix, Baseball
My of the favorites of my guests is Dokapon Kingdom a RPG/Party game mix.
Let's Tap is a novel multiplayer game where you don't even touch the controller. Racing is particularly fun.
One of the Rayman Rabbids titles would be a good addition. Probably the third (TV Party) or there's a collection of the first three.
House of the Dead: Overkill - Good for drinking buddys (not kids)
Punch-Out has a multiplayer mode and is a fun Wii game for single players too.
Consider one of the Hasbro Game Nights. I think the 2nd is best but havn't played them much. Again a collection is available.
Second: Brain Academy, Kirby EY, Kirby RtDL (4 player), DKCR, Conduit 2 (split-screen), DBZBT3, MH3, Excitbots, Rayman Origins (4 player)
Wiiware: There's a ton. Dart Rage, Pong Toss, Tetris Party, TV Show King are good for general audiences. There's a lot of crap though so you have to be careful. Folks at wiiwarewave.com might have better suggestions.