I highly doubt it.

@kitler eh, well it could not win it if it sucks >_>

I mean... My pick is Skyrim to win it. Though it might not be my favorite.

Deus Ex 3: HR Might be mine. I'm not sure obviously.
ME3: Ditto
Dead Space 2 is mine so far.

And Tomb Raider if they make strides in quality like they did with LCatGoL. Then that maybe. As well as others for me.

I'm not sure how you came to your 60% prediction of GOTY for Infamous 2

Let's look at the games you mentioned-

Zelda SS Preceded by Zelda TP. Metacritic score = 95

U3 preceded by U2. Meta score = 96

ME3 preceded by ME2. Meta score = 96

New Assassins Creed preceded by AC:B. Meta score = 90

And finally

Infamous 2 preceded by Infamous. Meta score = 85

So...how did you come to your conclusion that Infamous 2 has a majority chance of GOTY? Did you rely on a few action packed gameplay vids that look a lot like the original (but of course better looking)?

The second games from sucker punch are always better. They said themselves they are looking to beat naughty dog. PLUS, uncharted 1 had a lower score than uncharted 2 proving that the part II could always be 100 percent better. PLUS the fact that inFAMOUS 2 is gonna be fucking awesome. But your right my 60% comes from bias =p

I'd say 1% to be honest. Reasons alot of people have already given. 

I can't wait to come back to this thread hehehehehehehe

Zero to slim, given LBP 2 seems to be out of the running, so only few titles remain. This is coming from infamous 2 fan, but one that is realistic. 

Skyrim will easily earn the most GOTY awards including the VGA Spike one.

I'm interested to see Mass Effect 3 Vs uncharted 3 since UC2 and ME2 are considered some of the best games of this gen. Graces F comes out this year so it has no hope :P but yeah in all seriousness, it has a slight chance to win but I doubt it.

I second Skyrim and L.A Noire because every year is predictable and these games fit the bill. Personally Dark Souls is my GOTY no competition :)