Wow... Now I'm having naughty ideas about standard (best) Sheperd... YUM!

He could shoot and move in Degeneration

Necromorphs > Tank Controls

LOL! this. seriously as buff as the made Chris in RE5 he could take on the Hulk...wait.

OT: Issac would show them how it's done!!!

Isaac would mop the floor with them.  He honestly is an awesome character and as much as I love the older Resident Evil games none of the characters had to deal with the kind of shit Isaac has had to....I mean the universe of Dead Space is just messed up and the Necromorphs would absolutley destroy Chris and Jill.

Great thread!!!  I love stuff like this.

I think Isaac would have difficulty surving in the RE universe because he would have to adjust to bullets, not minning tools and he would loose stasis.  Isaac without his minning tools would completely change his character.  I know he can keep his old weapons but earth wouldn't have the ammo and stasis stations to refill.  Plus, he's going insane and zombies may push him over the edge.  Plus, he'd have to get used to not being able to shoot and walk at the same time.

Jill and Chris, I dunno.  It depends if they can get used to walking and shooting at the same time.  They would also have to adjust to new weapons because the Ishimaru(I know it's spelled wrong) doesn't have bullets as far as I know.  Also, it would depend on how long it takes for them to start going insane and wether they can hold it off.  I think they could adjust though cause they've killed some pretty difficult enemies standing still, imagine what they can do walking.

Jill and Chris?  No... but Leon S. Kennedy and Claire Redfield would easily

anybody that can survive all the crap that goes on in the Biohazard universe can easily survive Dead Space.